But it will be a sad day when my Mythoclast gets replaced. :(

They're just missing in action.

Seriously, though,

Fatebringer will never NOT be the best weapon.

Not just Fatebringer... but with House of Wolves on the horizon, are we finally approaching the day when our level 300 weapons just won't cut it anymore?

If so, what 300 weapons will you miss using the most? Fatebringer is certainly the one I'll have the toughest time parting with... it will be a sad day when it stops being the force of nature it currently is.

On that note, do you think you might end up deleting any of your current weapons? Does this change your view on vault space at all?

Maybe maybe not.

When you step up an archetype, you end up doing about 200 more damage to regular enemies. For 331 attack, it's 1500 / 1700 / 1900 approximately.

When you step from 27x to 300 to 331, the jump is about the same.

Right now fatebringer does about as much damage as a low impact 331 hand cannon, so in House of Wolves it will deal about 400 less damage than a new medium impact legendary.

So this is only a problem if you are fighting an enemy whose HP falls in that magic range of between 1500 and 1900 HP. If it's under, it'll still die in one shot. You'll probably be able to one shot thralls still. If it's over, then it will take 2 shots with whatever hand cannon you use. Also remember you get damage buffs on certain enemies using explosive rounds.

Right now, you can pretty much use any hand cannon on Cabal, since at higher levels nothing can one shot them. Except maybe a triple stacked hawkmoon. This is also why I tend to use Scout Rifles vs the Cabal, since the instakill advantage of the hand cannon is gone.

The firefly perk and arc damage will be very good.

Go do an activity with a Word of Crota that is not fully leveled. That will simulate Fatebringer on House of Wolves enemies. Then just remember fatebringer will be better.

You get a lot of milage with hand cannons in PvE.

I am still hoping they increase the damage at least somewhat to stop them from being useless.

However, I find the 300 has no problem dealing with enemies, so maybe the curve is not as great as you think?

I was just thinking this very thing earlier today.

I'll miss pretty much all of my VoG Weapons:
Fatebringer
Vision of Confluence
Praedyth's Revenge
Corrective Measure

Plus these:
The Devil You Know (although Fatebringer already replaced this for me)
The Swarm

And that's about it.

As for clearing out my vault space? Not really, it's full of exotics, a Khostov & Stranger's Rifle, & Legendaries that I think might be good (some just for PVP), but I haven't gotten around to using. I really need to figure out what perks I enjoy on what weapons so I can junk some of these.

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I like the way they set up the weapons, overall. It means that in the Crucible (outside of Iron Banner), on patrols, in story missions (as long as you're not on the highest levels), and in lower-level strikes, you can pretty much use whatever you want, and there are rare, uncommon, and occasionally even common (white-grade) weapons that outperform legendary and exotic weapons in those cases. I have this white-grade sniper, Candace-B, that I picked up a while back with really high impact that's pretty nice in the Crucible-- or it would be if I was much of a sniper; I have a green-grade shotgun with the extended slide perk I've been playing around with; I have another green-grade shotgun with "Shot Package" (two now actually) that I'd still be using if I hadn't had the good fortune to get a rare one with the same perk; I have a bunch of blue-grade weapons that I still use... so yeah, good weapons should continue to be good weapons, just their range of usefulness will be a little smaller.
The new raid weapons will be better against high-level enemies of course. Your current weapons will seem like toys by comparison when you get a Hookmoon, The Sturgeon's Rifle, or Fate of All Flounders.