Disclaimer: I would never dream of robbing myself, Marty, or the game of it's true music selection in the first dozen playthroughs (if that's possible)

That being said, I have always enjoyed playing the Halo games with some custom soundtracks, especially during Multiplayer, to see what kind of juxtaposition can occur and new perspective on game elements or scenes.

A good example is that I found Die Young by Black Sabbath goes really well with Rally Point Omega at the end of Reach.

what kind of music do you think will also reflect the spirit or add a new perspective to Destiny? Spanish guitar? Heavy metal? polka?

P.S. I've f5'd DBO too many times today to not kick something out there.