Generally, no (Destiny)

by CruelLEGACEY , Toronto, Thursday, June 16, 2016, 14:24 (2868 days ago) @ marmot 1333

This technique works because the source is 5.1 sound and there is a center channel. Most music is just mixed in stereo and vocals fluctuate across frequencies, mixing in with other instrumentation.

Depending on the label and genre, it is sometimes not so hard to find singles with an acapella or instrumental mix.

Edit: I reread Cody's suggestion and it sounds like that source is just stereo. So.. maybe?

So Cody's suggestion should work well in this instance because voice-over tracks for TV/Movies/Games are almost always perfectly centered in the mix, meaning the voice in the left channel is exactly the same as the voice in the right channel.

Vocals in music are more complicated because there are often multiple layers with multiple takes, spread out to various points in the stereo range. So the voices you hear in the left channel are often not identical to the voices in the right channel. There will be a decent amount of overlap, so it would still partially work, but not as effectively.